PCP

Phenylcyclohexyl piperidine (phenylcyclodine, PCP, angel dust) is a member of the arylcyclohexylamine class of dissociative anesthetic drugs. It is a DEA Schedule II controlled substance in the United States, Schedule I in Canada, and Class A drug in the United Kingdom.

PCP was first synthesized by Harold Maddox at Parke, Davis & Co. in 1926 and was approved as an investigational drug for anesthesia during the 1950s. However, due to its dangerous side effects and the 1962 creation of the more predictable dissociative anesthetic, ketamine, PCP was discontinued for human medical use in 1965 and from veterinary use in 1978. It is primarily used recreationally as a drug of abuse.

Effects of PCP range dramatically and are dose-dependent. Low doses produce a feeling of numbness and intoxication similar to heavy drunkenness and moderate doses produce the anesthetic effect once sought for medical purposes. High doses of PCP can lead to hallucinations, including loss of self-awareness or a sense of separateness from oneself, paranoia, euphoria or dysphoria, agitation and aggression, as well as suicidal ideation and psychosis resembling schizophrenic episodes. 

Acting as an antagonist to the N-Methyl-D-aspartate (NMDA) receptor, PCP can induce hallucinations, disorientation, mania, and delirium. It has been shown to act on the D1-type spiny neurons of the nucleus accumbens to produce conditioned place aversion/preference and lead to addiction.

Testing for multiple drugs is important for individual patient care as well as for understanding usage trends for community care. Conventional methods for detecting drugs of abuse in biological samples include enzymatic immunosorbent assays (EIA or ELISA) and lateral flow tests. Pyxis provides PCP-BSA antigen conjugates and PCP monoclonal antibodies useful for both qualitative and quantitative determination by immunoassays in biological fluids as well as a wide range of drug antigen conjugates and drug antibodies for drug test batteries, including but not limited to:

            Amphetamines

            Benzodiazepines

            Cannabinoids, natural and synthetic

            Cocaine

            Ketamine

            PCP

            Opioids

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